6 powerful antioxidants for cell renewal

Long gone are the days when ageing was seen as an inevitable decline. Today, the pursuit of a healthier life has become a priority for the wise and forward-thinking. Are you one of the health-nerds, trying to improve your health as well as that of your loved ones?

Discover the benefits of the 6 powerful antioxidants for cell renewal, that should be in the anti-ageing supplement stack of everyone concerned about their health.

Antioxidants for cell renewal

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Ageing at the cellular level

Cells are the building blocks of our body, tirelessly performing their functions’ day in and day out. Over time, they begin to show signs of wear and tear.

DNA damage, cellular mutations, and a decrease in the efficiency of cellular processes all play a role in the ageing process. These changes can lead to a range of age-related health issues, from decreased energy levels to increased susceptibility to diseases

Genes account for only about 20% of the ageing process. Your lifestyle and environment play a much bigger role.

The role of oxidative stress and free radicals in ageing

Central to the ageing process is the concept of oxidative stress. Oxidative stress occurs when there is an imbalance between harmful molecules called free radicals and the body’s defence mechanisms, such as antioxidants. 

Free radicals and antioxidants imbalance cause oxidative stress

Free radicals are highly reactive molecules that can damage cells, carbohydrates, lipids, proteins, and DNA. They are by-products of normal metabolic processes, but their levels can increase due to factors like pollution, UV radiation, and unhealthy lifestyles.

When free radicals outnumber antioxidants, they wreak havoc within our cells, leading to accelerated ageing and an increased risk of age-related diseases. Oxidative stress is a silent killer. It slowly erodes the vitality of our cells and our overall well-being, until it’s too late.

The importance of antioxidants for cell renewal

Antioxidants are a group of molecules that have the remarkable ability to neutralise free radicals, preventing them from causing further harm. They act as cellular protectors, helping to repair damaged DNA, proteins, and cell membranes.

How do antioxidants work

In the quest for longevity, antioxidants play a pivotal role. By providing our cells with the defence they need against oxidative stress, antioxidants help slow down the ageing process and reduce the risk of age-related diseases. 

The synergy of different antioxidants working together can be particularly effective, as they reinforce each other’s protective abilities.

The 6 powerful antioxidants you should know about

The following ingredients focus on three primary mechanisms: promoting autophagy, clearing out senescent cells, and providing defence against oxidative stress, setting the stage for optimal cellular revitalisation.

6 potent antioxidants for cell renewal

Let’s delve into the science rooting for these ingredients. We chose them for many reasons, and we’d love to share them with you.

Spermidine: Supporting cellular health

Spermidine is a naturally occurring polyamine, that can also be found in wheat germ or soy products. It has gained significant attention in the longevity field for its vital role in autophagy, our cellular cleansing mechanism. 

Autophagy helps remove damaged cellular components, promoting cellular rejuvenation.

Several studies proved the administration of Spermidine to enhance autophagy, supporting overall health and potentially extending cellular lifespan [1].

Quercetin: Fighting inflammation and promoting heart health

Quercetin is a natural flavonoid with potent antioxidant and anti-inflammatory properties. It has been widely studied for its benefits in reducing inflammation, particularly in relation to heart health.

Research suggests that Quercetin can help lower blood pressure, reduce cholesterol levels, and mitigate the risk of cardiovascular diseases, making it a valuable addition to a longevity-focused regimen. It’s also a well-recognised senolytic [2].

Learn more on Quercetin benefits here.

Fisetin: Enhancing cognitive function and longevity

Fisetin is another flavonoid found in certain fruits and vegetables, known for its cognitive-enhancing properties. It acts as a neuroprotective agent, supporting brain health and function.

Studies indicate that Fisetin has the potential to improve memory, protect against age-related cognitive decline [3], and extend lifespan by targeting pathways associated with ageing. It is currently the most powerful senolytic known.

Senolytics, in a nutshell, are your body’s clean-up crew. They’re a group of drugs that work selectively with aged cells (senescent cells), encouraging them to exit the scene gracefully.

Selenium: Protecting against oxidative damage

Selenium is a trace mineral essential for the proper functioning of antioxidant enzymes, like glutathione peroxidase. It plays a pivotal role in protecting cells from free radicals.

Scientific research highlights Selenium’s importance in reducing the risk of chronic diseases and supporting the body’s natural defences against oxidative stress. It enhances the immune system function, help with normal thyroid function and the maintenance of healthy nails, hair and skin [4].

PQQ (Pyrroloquinoline Quinone): Boosting mitochondrial function

PQQ is an antioxidant that supports mitochondrial health, the energy powerhouses of our cells. It promotes the growth of new mitochondria (mitochondrial biogenesis) and helps enhance their efficiency.

Studies suggest that PQQ may improve cognitive function, increase energy production, and contribute to overall vitality by optimising mitochondrial function [5].

Ergothioneine: Defending against oxidative stress

Ergothioneine is a naturally occurring amino acid-like compound with potent antioxidant properties. It stands out for its ability to accumulate specifically in tissues exposed to oxidative stress.

Found in mushrooms, it is thought to support long-term health through its free radical scavenging and cell-protective properties [6]

Avea’s solution: The Cell Primer

The Avea Cell Primer.

Synergy of these antioxidants

We specifically chose this blend of antioxidants, not only for their individual merits, but also for their ability to complement and enhance the effects of the others

Mitochondrial support

PQQ and Selenium boost mitochondrial function and protect against oxidative damage. This not only provides an energy boost but also ensures that the cell’s energy factories are well-maintained.

Cellular cleanup

Spermidine aids in cellular autophagy, while Ergothioneine and Quercetin defend against further oxidative stress. Together, they promote cellular rejuvenation and longevity pathways.


Fisetin’s cognitive benefits are amplified when combined with other antioxidants like PQQ. This synergy not only supports brain health but also contributes to enhanced quality of life. Quercetin and Fisetin also work as the senolytic duo.

Clinical studies have shown the advantages of combining antioxidants for enhanced health benefits. The well known French Paradox includes a Mediterranean diet, rich in antioxidants like Quercetin (found in red wine) and Selenium (found in fish), which has been linked to a lower risk of heart disease. 

David Sinclair, renowned longevity researcher, takes Quercetin, Fisetin, Spermidine daily.

Learn more about David Sinclair’s anti-ageing supplements here.

Incorporating these antioxidants in your daily routine is a step toward unlocking your body’s full potential and embracing a future filled with vitality and well-being.

  • Target your ageing at the cellular and molecular level
  • Increase your energy levels and decrease your fatigue level
  • Enhance your mental clarity and sharpness

Key takeaway

Having a healthy mind and body will translate into better decision-making, increased productivity, and a higher quality of life.

By addressing the root causes of ageing and age-related diseases, these 6 potent antioxidants offer a form of insurance for your long-term health.

It’s an investment in a future where you can enjoy your passions and pursuits with a lower risk of health challenges holding you back. 

After all, ageing is not a destination; it’s a journey, and with the right tools, it can be a remarkable one. Allow yourself to an improved quality of life, allowing you to relish the experiences, relationships, and achievements that make life truly meaningful. 

Embrace the benefits of antioxidants in your daily life. They play a pivotal role in preserving the vitality of your cells, defending them against the relentless massacre of oxidative stress, and extending their functional lifespan.


By Aishani Rajarai

Aishani Rajarai is a scientific writer and neuroscience enthusiast. She holds a BSc in biochemistry and cell biology, and a minor in medicinal chemistry and chemical biology. Her mission at Avea is to bring the science of longevity through blog posts, newsletters, podcasts, and social media content to the public, so people can live a healthier, longer, and happier life.

Aishani Rajarai is a scientific writer and neuroscience enthusiast. She holds a BSc in biochemistry and cell biology, and a minor in medicinal chemistry and chemical biology. Her mission at Avea is to bring the science of longevity through blog posts, newsletters, podcasts, and social media content to the public, so people can live a healthier, longer, and happier life.