Apigenin benefits: your gateway to wellness and longevity

It’s now become mainstream, or simply smart, to look beyond pharmaceuticals for health solutions. Apigenin benefits might just be your gateway to ultimate wellness and longevity.

A cultural shift is occurring as people are no longer satisfied with simply treating symptoms. They want to optimise our health and extend their quality of life.

So step aside Big Pharma, nature’s back into the game. Discover the benefits of this plant-derived compound in improving healthspan.

What is Apigenin?

Apigenin is part of a group of plant compounds known as flavonoids. 

These are well-regarded for their antioxidant, anti-inflammatory, and anti-cancer properties. 

Flavonoids benefits

Apigenin is found abundantly in everyday foods like parsley and chamomile tea.

8 Apigenin benefits backed by science

Apigenin acts like a multipurpose tool for health. Lab studies have shown promise in everything from battling inflammation to combating certain types of cancer cells. Increasing numbers of clinical studies are now being conducted.

Apigenin benefits for brain health [1]

Animal studies suggest that Apigenin can positively influence neuron formation and strengthen the connections between brain cells. This may lead to improved memory and mental clarity. Preclinical studies also show Apigenin’s ability to reduce anxiety and promote brain function.

Apigenin benefits for immune health [2]

Apigenin is a highly potent anti-inflammatory compound. It suppresses enzymes and proteins that contribute to inflammation, and also neutralise free radicals that can damage DNA, lipids, proteins, and more. 

Evidence suggests Apigenin may help protect against parasites, microbes, and viruses. Limited clinical studies also support its potential benefits in improving immune health, signs of ageing, and reducing the risk for type II diabetes.

Apigenin benefits for cancer [3]

Optimistic, but not conclusive. Preclinical studies, mostly in vitro (cell cultures) and in vivo (animal models), have shown that Apigenin can interfere with various cellular processes related to cancer progression. 

These include inhibiting cell proliferation, inducing apoptosis (cell death), and impairing angiogenesis (the formation of new blood vessels that tumours need to grow). It’s also been observed to target specific signalling pathways that are dysregulated in cancer cells.

Apigenin benefits for heart health [4]

Preclinical studies show Apigenin’s benefits for the heart.  It has been found to possess vasorelaxant properties, meaning it can help relax our blood vessels, potentially aiding in lowering blood pressure. 

Its anti-inflammatory and antioxidant effects may contribute to reducing the risk of atherosclerosis, a condition where plaque builds up in the arteries.

Apigenin benefits for skin health [5]

As for the fountain of youth? Well, Apigenin’s antioxidant properties might also help here. Oxidative stress is a known culprit in skin ageing, and the antioxidant capacity of Apigenin could potentially protect your skin cells from damaging free radicals. 

Apigenin benefits for sleep [6]

Known for its calming effects, Apigenin might not only help you fall asleep, but may also enhance the quality of your rest.

It works by tickling the activity of neurotransmitters like GABA and melatonin, both vital players in your sleep game. Clinical trials have shown that an Apigenin-rich chamomile extract significantly enhanced sleep quality in the elderly.

Apigenin benefits for testosterone levels [7]

Apigenin might give you a lift with your testosterone levels. This hormone affects everything from your mood and bone health to your libido, so keeping it at optimal levels is crucial. 

Experimental studies suggest that Apigenin encourages your body to produce more testosterone, and it may even help you maintain those levels as you age. This could also lead to gains in muscle mass.

Apigenin benefits for blood sugar control [8]

If you’re looking to sweeten your health profile without the spike in blood sugar, Apigenin is on your side. It encourages your pancreas to release more insulin and help control your blood sugar. 

It also inhibits an enzyme– α-glucosidase– involved in turning carbs into sugar in your bloodstream. Apigenin helps slow down the sugar surge, keeping your blood sugar levels in check.

Apigenin benefits for bone health [9]

Apigenin could help in speeding up bone healing and even encourages the formation of new bone. Think of it as the architect and builder of your skeletal framework. Research also indicates it could shield your knee cartilage from damage, acting like a protective barrier in between your bones.

The biological mechanism behind Apigenin’s actions

Animal studies suggest that Apigenin may

  • impede genetic mutations occurring in cells that are exposed to toxins and bacteria.
  • play direct roles in the removal of free radicals.
  • inhibit tumor growth enzymes.
  • induce detoxification enzymes.
  • have anti-inflammatory ability that explain its effects on mental health, brain function, and immunological response.

Apigenin in natural supplements

There’s no official dietary recommendation yet for Apigenin. That said, supplements typically come in 50 mg capsules. Want a powerhouse combo? Pair it up with other supplements like NAD+ precursor or Magnesium for boosted results. 

The Vitality Bundle: Why do we use Apigenin in our supplements?

Avea Vitality Bundle

Our scientifically-backed Vitality Bundle consists of 

(1) the Avea NAD+ precursor (250mg)

(2) the Avea Booster – an ideal blend of 5 powerful antioxidants, including Resveratrol, Ubiquinol (CoQ10), Betaine, Pterostilbene, and Apigenin.

Together, this powerful duo:

  • Powers your cells for sustainable energy.
  • Revs up your metabolism & physical game.
  • Sharpens your memory & cognitive skills.
  • Strengthens your heart & dials down chronic disease risks.
  • Boosts mood, supports weight loss, and leaves your skin glowing.

By targeting age-related declines, such NMN & CoQ10, you ensure your body has the necessary nutrients to function its best.

We included Apigenin in our Booster supplement as it prevents NAD+ decline in the body, thanks to its CD38 inhibiting properties. It’s a perfect complement to our NAD+ precursor product.

NAD+ precursors will boost NAD+ levels, whilst Apigenin slows down and inhibits the breakdown of your NAD+ storage supply. They work as a powerful, healthy ageing combination. 

If that’s not enough, activating sirtuins by NAD+ regulates essential physiological processes, including the circadian rhythm, glucose and fat metabolism, and the healthy ageing process.

Avea customer review & study results

Safety and side effects:

  • Apigenin is generally safe with low toxicity.
  • Consuming it from food and supplements hasn’t been linked to severe health issues.
  • High doses may cause side effects like nausea, skin irritation, and sedation. (Avea supplements are double-tested for purity and ideal dosage)
  • May interact with certain medications, particularly blood thinners.
  • Consult a healthcare provider if you have liver or kidney issues or before starting any Apigenin supplements.


By Aishani Rajarai

Aishani Rajarai is a scientific writer and neuroscience enthusiast. She holds a BSc in biochemistry and cell biology, and a minor in medicinal chemistry and chemical biology. Her mission at Avea is to bring the science of longevity through blog posts, newsletters, podcasts, and social media content to the public, so people can live a healthier, longer, and happier life.

Aishani Rajarai is a scientific writer and neuroscience enthusiast. She holds a BSc in biochemistry and cell biology, and a minor in medicinal chemistry and chemical biology. Her mission at Avea is to bring the science of longevity through blog posts, newsletters, podcasts, and social media content to the public, so people can live a healthier, longer, and happier life.