In recent years, it’s become both mainstream and smart to seek health solutions beyond traditional pharmaceuticals. Apigenin, a naturally occurring compound, might just be the gateway to ultimate wellness and longevity.
As a cultural shift moves people away from symptom-focused treatments, the focus is now on optimising health and extending the quality of life.
Nature is reclaiming its place in the spotlight, and Apigenin—a plant-derived powerhouse—offers a promising edge in improving healthspan.
Read on to explore its benefits, dosage, safety, and why it’s gaining attention as a top supplement choice.
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What is Apigenin?
Apigenin is part of a group of plant compounds known as flavonoids.
These are well-regarded for their antioxidant, anti-inflammatory, and anti-cancer properties.
Apigenin can be found in chamomile, yarrow, thyme, cherries, tea, olives, broccoli and parsley (especially dried parsley). However, it’s much easier to get a worthwhile amount when taking it in supplement form.
9 Apigenin benefits backed by science
Apigenin can act like a multipurpose tool for health. Lab studies have shown promise in everything from battling inflammation to combating certain types of cancer cells. Increasing numbers of clinical studies are now being conducted.
1. Apigenin benefits for brain health
Animal studies suggest that Apigenin can positively influence neuron formation and strengthen the connections between brain cells. This may lead to improved memory and mental clarity. Preclinical studies also show Apigenin’s ability to reduce anxiety and promote brain function.[1]
2. Apigenin benefits for immune health
Apigenin is a highly potent anti-inflammatory compound. It suppresses enzymes and proteins that contribute to inflammation, and also neutralise free radicals that can damage DNA, lipids, proteins, and more.
Evidence suggests Apigenin may help protect against parasites, microbes, and viruses. Limited clinical studies also support its potential benefits in improving immune health, signs of ageing, and reducing the risk for type II diabetes.[2]
3. Apigenin benefits for cancer
Optimistic, but not conclusive. Preclinical studies, mostly in vitro (cell cultures) and in vivo (animal models), have shown that Apigenin can interfere with various cellular processes related to cancer progression.
These include inhibiting cell proliferation, inducing apoptosis (cell death), and impairing angiogenesis (the formation of new blood vessels that tumours need to grow). It’s also been observed to target specific signalling pathways that are dysregulated in cancer cells.[3]
Vitality Bundle: NMN, Apigenin, Resveratrol and more
- Target signs of ageing from within.
- Activate sustained energy and sharper focus.
- Improve physical performance and metabolism.
- Support skin health and resilience.
4. Apigenin benefits for heart health
Preclinical studies show Apigenin’s benefits for the heart. It has been found to possess vasorelaxant properties, meaning it can help relax our blood vessels, potentially aiding in lowering blood pressure.
Its anti-inflammatory and antioxidant effects may contribute to reducing the risk of atherosclerosis, a condition where plaque builds up in the arteries.[4]
5. Apigenin benefits for skin health
As for the fountain of youth? Well, Apigenin’s antioxidant properties might also help here. Oxidative stress is a known culprit in skin ageing, and the antioxidant capacity of Apigenin could potentially protect your skin cells from damaging free radicals. [5]
6. Apigenin benefits for sleep
Known for its calming effects, Apigenin might not only help you fall asleep, but may also enhance the quality of your rest.
It works by tickling the activity of neurotransmitters like GABA and melatonin, both vital players in your sleep game. Clinical trials have shown that an Apigenin-rich chamomile extract significantly enhanced sleep quality in the elderly.[6]
7. Apigenin benefits for testosterone levels
Apigenin might give you a lift with your testosterone levels. This hormone affects everything from your mood and bone health to your libido, so keeping it at optimal levels is crucial.
Experimental studies suggest that Apigenin encourages your body to produce more testosterone, and it may even help you maintain those levels as you age. This could also lead to gains in muscle mass.[7]
8. Apigenin benefits for blood sugar control
If you’re looking to sweeten your health profile without the spike in blood sugar, Apigenin is on your side. It encourages your pancreas to release more insulin and help control your blood sugar.
It also inhibits an enzyme– α-glucosidase– involved in turning carbs into sugar in your bloodstream. Apigenin helps slow down the sugar surge, keeping your blood sugar levels in check.[8]
9. Apigenin benefits for bone health
Apigenin could help in speeding up bone healing and even encourages the formation of new bone. Think of it as the architect and builder of your skeletal framework. Research also indicates it could shield your knee cartilage from damage, acting like a protective barrier in between your bones.[9]
How does Apigenin work?
Animal studies suggest that Apigenin may
- impede genetic mutations occurring in cells that are exposed to toxins and bacteria.
- play direct roles in the removal of free radicals.
- inhibit tumour growth enzymes.
- induce detoxification enzymes.
- have anti-inflammatory ability that explain its effects on mental health, brain function, and immunological response.
How much Apigenin should you take?
There’s no official dietary recommendation yet for Apigenin. That said, supplements typically come in 50 mg capsules. Want a powerhouse combo? Pair it up with other supplements like NAD+ precursor or Resveratrol for boosted results.
The Vitality Bundle: A synergistic solution
Vitality Bundle: NMN, Apigenin, Resveratrol and more
- Target signs of ageing from within.
- Activate sustained energy and sharper focus.
- Improve physical performance and metabolism.
- Support skin health and resilience.
When it comes to cellular health, it’s not just about taking individual ingredients—it’s about how they work together.
At a biological level, your cells thrive on teamwork, where each nutrient plays a unique yet complementary role in maintaining optimal function.
Apigenin is no exception. Its benefits multiply when paired with other powerful ingredients found in Avea’s Vitality Bundle that consists of
(1) the Avea NAD+ precursor (250mg)
(2) the Avea Booster – an ideal blend of 5 powerful antioxidants, including Resveratrol, Ubiquinol (CoQ10), Betaine, Pterostilbene, Nicotinamide & Apigenin.
Here’s how:
1. Apigenin + Avea NAD+ precursor (NMN)
Boosting NAD+ levels to optimal levels
Apigenin is a standout when it comes to cellular health because it inhibits CD38, an enzyme that depletes NAD+—a critical molecule for energy production and DNA repair.
By reducing CD38 activity, Apigenin preserves and optimises the NAD+ levels in your cells, allowing them to function more efficiently.
Why NAD+ precursor works with Apigenin:
Avea’s NMN directly fuels your body’s NAD+ synthesis by providing the building blocks needed to increase NAD+ levels. When paired with Apigenin, the combination creates a powerful synergy:
- Apigenin ensures minimal NAD+ is wasted by CD38.
- NMN replenishes and elevates NAD+ stores, amplifying your energy metabolism and cellular repair processes.
The result? Your cells have more fuel to perform critical tasks like DNA repair and managing oxidative stress, keeping you energised and resilient.
2. Apigenin and the 5 antioxidants in the NAD+ Booster
A masterclass in antioxidant synergy
Apigenin doesn’t stop at preserving NAD+—it also plays a role in reducing oxidative stress and inflammation, making it an ideal partner for Avea Booster’s blend of five potent antioxidants. Together, they provide unparalleled protection for your cells.
Here’s how the synergy works:
- Resveratrol & Pterostilbene: These polyphenols enhance Apigenin’s anti-inflammatory effects, reducing stress at the cellular level.
- Ubiquinol (CoQ10): Supports mitochondrial health, ensuring cells have the energy they need to repair and regenerate effectively.
- Betaine: Works alongside Apigenin to protect your cells from environmental and metabolic stressors, ensuring stability in DNA and protein structures.
- Nicotinamide: Complements NAD+ production, while Apigenin keeps NAD+ levels stable, creating a one-two punch for optimal energy and cellular repair.
Together, this blend maximises antioxidant protection, reduces inflammation, and ensures your mitochondria (the powerhouse of the cell) operate at peak performance.
Health benefits you can expect
- Sustainable energy: Powers cells for optimal energy production.
- Enhanced metabolism: Supports efficient metabolic function and physical performance.
- Cognitive clarity: Promotes sharper memory and improved cognitive health.
- Heart health: Strengthens cardiovascular function and reduces chronic health risks.
- Holistic wellness: Supports healthy weight, skin vitality, and overall balance.
- Improved sleep: Supports restorative sleep for better recovery and balance.
Safety and side effects of Apigenin
- Apigenin is generally safe with low toxicity.
- Consuming it from food and supplements hasn’t been linked to severe health issues.
- High doses may cause side effects like nausea, skin irritation, and sedation. (Avea supplements are double-tested for purity and ideal dosage)
- May interact with certain medications, particularly blood thinners.
- Consult a healthcare provider if you have liver or kidney issues or before starting any Apigenin supplements.
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