The Complete Guide to AVEA’s Booster Ingredients: Unlocking Your NAD+ Potential

You’ve probably heard about NAD+ (nicotinamide adenine dinucleotide) – the cellular coenzyme that powers nearly everything your body does. From converting food into energy to repairing DNA and regulating your sleep-wake cycle, NAD+ is fundamental to life itself.

Here’s the challenge: NAD+ levels decline by as much as 50% between the ages of 40 and 60. This decline isn’t just a number – it manifests as fatigue, brain fog, reduced physical performance, and accelerated aging.

Enter NMN (nicotinamide mononucleotide), the breakthrough NAD+ precursor that efficiently converts into NAD+ in your cells. But here’s what most people don’t know: taking NMN alone is like filling a leaky bucket. To truly optimize NAD+ levels, you need to address three critical factors:

1. NAD+ Production – Building more NAD+
2. NAD+ Protection – Preventing its breakdown
3. NAD+ Utilization – Ensuring your cells can actually use it

This is where AVEA’s Booster comes in—a scientifically formulated blend designed to work synergistically with NMN for maximum cellular benefit.

The Three Pathways That Control Your NAD+ Levels

Understanding the NAD+ Cycle

Think of cellular NAD+ like a rechargeable battery. Your body has several ways to “charge” this battery:

• The Salvage Pathway – The most important route, recycling used NAD+ back into its active form. This pathway processes about 85% of your NAD+.
• The de novo Pathway – Building NAD+ from scratch using tryptophan from your diet.
• The Preiss-Handler Pathway – Converting vitamin B3 (nicotinic acid) directly into NAD+.

But production is only half the story. Your NAD+ is constantly being consumed by:

• Sirtuins – Proteins that regulate cellular health, metabolism, and longevity
• PARPs – Enzymes involved in DNA repair
• CD38 – An enzyme that breaks down NAD+ (and becomes more active with age)
• NADases – Various enzymes that degrade NAD+

The critical insight: As you age, CD38 activity increases dramatically, consuming more and more of your precious NAD+. Studies show that CD38 can account for up to 90% of NAD+ degradation in some tissues.

The 6 Ingredients in AVEA’s Booster – And How They Work Together

AVEA’s Booster isn’t just a random collection of antioxidants. Each ingredient targets a specific mechanism in the NAD+ cycle, creating a synergistic effect that’s greater than the sum of its parts.

1. Nicotinamide/Vitamin B3 (16mg): The NAD+ Precursor Booster

What it is: Also known as niacinamide, this is one of the three forms of vitamin B3 and a direct NAD+ precursor.

How it works: Nicotinamide enters the salvage pathway – the body’s main route for recycling NAD+. It’s converted to nicotinamide mononucleotide (NMN) through the enzyme NAMPT, then to NAD+.

The science: While you’re taking NMN directly, adding a small amount of nicotinamide provides additional raw material for the salvage pathway. It’s particularly important because when sirtuins use NAD+, they release nicotinamide as a byproduct, which the body recycles back into NAD+.

Studies have demonstrated that nicotinamide can:

• Enhance cellular energy production
• Protect against oxidative stress
• Support healthy inflammatory responses
• Complement other NAD+ precursors

Why it matters: Having multiple entry points into the NAD+ production system ensures more consistent and stable NAD+ levels throughout the day.

Synergy with NMN: While NMN provides a direct, powerful boost to NAD+, nicotinamide supports the ongoing recycling and maintenance of those levels, creating a more sustainable elevation.

Simply put, longevity supplements help you stay strong, sharp, and energetic as you age.

2. Resveratrol (150mg): The Mitochondrial Activator

What it is: A polyphenol found naturally in red grapes, berries, and Japanese knotweed.

How it works: Resveratrol activates SIRT1, one of the most important longevity proteins in your body. Think of SIRT1 as a master regulator that needs NAD+ to function – it’s like the ignition key that starts your cellular engine.

The science: Research demonstrates that resveratrol enhances mitochondrial biogenesis (the creation of new mitochondria) through a pathway involving SIRT1 and PGC-1α, a protein that acts as a “mitochondrial master switch.” This means your cells literally produce more energy-generating powerhouses.

Additionally, resveratrol activates AMPK (AMP-activated protein kinase), often called the body’s “metabolic master switch,” which increases NAD+ levels in skeletal muscle. This creates a positive feedback loop: resveratrol helps produce more NAD+, which then fuels more SIRT1 activity.

Why it matters: More mitochondria plus more efficient mitochondria equals significantly more cellular energy. Studies show that moderate doses of resveratrol can increase NAD+ levels while improving mitochondrial function – but only when SIRT1 is present, proving the specificity of this mechanism.

Synergy with NMN: By activating SIRT1, resveratrol ensures that the NAD+ produced from NMN is actually being used for beneficial cellular processes rather than sitting idle.

3. Ubiquinol/CoQ10 (100mg): The Energy Amplifier

What it is: The reduced, active form of Coenzyme Q10 – a compound naturally produced by your body but declining significantly with age.

How it works: Ubiquinol plays a crucial role in the electron transport chain within your mitochondria, where ATP (cellular energy) is produced. Specifically, it’s involved in Complex I, which oxidizes NADH to NAD+.

The science: Here’s where things get fascinating. Mitochondrial Complex I is a transmembrane protein complex that oxidizes NADH to NAD+ while reducing ubiquinone-10 to ubiquinol-10. This process is fundamental to cellular respiration.

Research shows that ubiquinol supplementation can:

• Increase Complex I and Complex IV activity in mitochondria
• Activate SIRT1 and PGC-1α through increased cAMP levels
• Enhance mitochondrial biogenesis
• Reduce oxidative stress markers
• Support the regeneration of NAD+ from NADH

A study on senescence-accelerated mice found that ubiquinol supplementation suppressed age-related decreases in Complex I activity, suggesting it helps maintain mitochondrial NAD+ recycling capacity.

Why it matters: NAD+ and CoQ10 work together in the mitochondrial electron transport chain. NAD+ is essential for oxidative phosphorylation, while CoQ10 supports the electron transport chain and acts as an antioxidant. Combined, they enhance ATP production and protect against mitochondrial dysfunction.

Ubiquinol is up to 8 times more bioavailable than standard CoQ10 (ubiquinone), meaning you get significantly more benefit from the same dose.

Synergy with NMN: CoQ10 and NAD+ are like dance partners in the mitochondrial energy production system. CoQ10 helps regenerate NAD+ from NADH, creating a recycling loop that makes both molecules more effective. This synergistic effect can significantly improve energy levels and reduce fatigue.

4. Apigenin (50mg): The NAD+ Protector

What it is: A flavonoid abundant in parsley, celery, chamomile, and citrus fruits.

How it works: Apigenin is a powerful inhibitor of CD38, the enzyme responsible for breaking down NAD+. As you age, CD38 activity increases, creating a “NAD+ drain” in your cells.

The science: Groundbreaking research has shown that CD38 is the primary regulator of intracellular NAD+ levels in mammalian tissues. When CD38 activity increases (which happens naturally with aging), your NAD+ levels plummet, even if you’re producing plenty of it.

Studies on apigenin demonstrate that it can:

• Significantly reduce CD38 expression
• Restore the NAD+/NADH ratio in cells
• Increase SIRT3 activity in mitochondria (reducing oxidative stress)
• Nearly double NAD+ levels in liver tissue

In one study on diabetic rats, apigenin treatment increased the intracellular NAD+/NADH ratio and improved mitochondrial antioxidative enzyme activity by reducing CD38 expression.

Why it matters: Imagine trying to fill a bathtub while the drain is open. That’s what taking NMN alone is like when CD38 is highly active. Apigenin essentially “plugs the drain,” allowing your NAD+ levels to rise and stay elevated.

Synergy with NMN: This is perhaps the most crucial ingredient in Booster. By inhibiting CD38, apigenin ensures that the NAD+ produced from NMN isn’t immediately broken down, dramatically extending its effectiveness.

5. Pterostilbene (50mg): The Enhanced Resveratrol

What it is: A naturally occurring compound structurally similar to resveratrol, found in blueberries and grapes. Think of it as “resveratrol 2.0.”

How it works: Pterostilbene activates SIRT1 just like resveratrol, but with superior bioavailability. The key difference? Two methoxy groups instead of hydroxyl groups, which makes it more fat-soluble and up to 4 times more bioavailable than resveratrol.

The science: Pterostilbene crosses cell membranes more easily and has a longer half-life in the body (about 7-8 times longer than resveratrol). This means it stays active in your system longer, providing sustained SIRT1 activation.

Studies show pterostilbene:

• Enhances SIRT1 activity and mitochondrial function
• Supports cellular repair mechanisms
• Provides potent antioxidant protection
• May improve NMN bioavailability

Why it matters: While resveratrol provides immediate SIRT1 activation, pterostilbene offers extended, sustained activation. Together, they create both rapid and long-lasting benefits.

Synergy with NMN: The combination of resveratrol and pterostilbene ensures comprehensive SIRT1 activation – both immediate and sustained – maximizing the beneficial effects of elevated NAD+ levels.

6. Betaine/TMG (50mg): The Methylation Supporter

What it is: Trimethylglycine (TMG), also called betaine, is a compound naturally found in beets, spinach, and whole grains.

How it works: TMG is a methyl donor, providing CH3 methyl groups that are essential for hundreds of biochemical reactions in your body, including the conversion of NMN to NAD+.

The science: Here’s the key point most people miss: when NMN is converted to NAD+, and when NAD+ is used and recycled, these processes consume methyl groups. Without sufficient methylation capacity, your body can’t efficiently process NMN or maintain the NAD+ cycle.

TMG provides methyl groups through the betaine homocysteine methyltransferase (BHMT) pathway, which converts homocysteine back to methionine. Methionine then produces S-adenosylmethionine (SAMe), the body’s universal methyl donor.

This pathway is particularly important because it’s independent of folate and vitamin B12, meaning it works even if you have genetic variations (like MTHFR mutations) that affect other methylation pathways.

Why it matters: Methylation is involved in:

• DNA synthesis and repair
• Gene expression regulation
• Neurotransmitter production
• Detoxification
• NAD+ metabolism

Without adequate methyl donors, taking high doses of NMN could theoretically deplete your methyl pool, potentially increasing homocysteine levels (a cardiovascular risk factor).

Synergy with NMN: TMG ensures that your body has the biochemical resources it needs to efficiently convert NMN to NAD+ and maintain healthy methylation throughout the NAD+ cycle. Think of it as providing the raw materials needed for the factory to run smoothly.

Bioavailability Focus

AVEA’s Booster is formulated with bioavailability as a top priority:

• Ubiquinol vs Ubiquinone: Up to 8x more absorbable
• Olive oil carrier: Enhances absorption of fat-soluble ingredients (resveratrol, pterostilbene, CoQ10)
• Proper dosing: Each ingredient at clinically relevant doses, not just “fairy dusted”

Synergistic combinations: Ingredients chosen to enhance each other’s effects

How These Ingredients Work Together: The Synergy Effect

The real magic of AVEA’s Booster isn’t in any single ingredient – it’s in how they work together to create a comprehensive NAD+ optimization system:

Step 1: Production

• NMN (from your NAD+ Precursor) efficiently converts to NAD+
• Resveratrol and Pterostilbene activate SIRT1 to utilize that NAD+ beneficially
• Nicotinamide supports the salvage pathway for continuous recycling

Step 2: Protection

• Apigenin inhibits CD38, preventing NAD+ breakdown
• This dramatically extends the half-life of your NAD+ levels
• More NAD+ remains available for cellular functions

Step 3: Utilization

• Ubiquinol optimizes mitochondrial function, helping convert NADH back to NAD+
• Resveratrol and pterostilbene activate SIRT1, ensuring NAD+ is used for longevity-promoting activities
• Betaine provides methyl groups needed for NAD+ metabolism

Step 4: Amplification

• The combination creates a positive feedback loop
• Better mitochondrial function → more efficient NAD+ recycling
• Activated sirtuins → improved cellular health
• Protected NAD+ pools → sustained energy levels

The result? A comprehensive system that doesn’t just increase NAD+ temporarily, but optimises the entire cellular energy ecosystem for lasting benefits.

Why Take the Vitality Bundle (NMN + Booster)?

The Science of Synergy

Taking NMN alone is like adding more water to that leaky bucket we mentioned earlier. You’ll see some benefits, but you’re fighting an uphill battle against:

1. CD38-mediated NAD+ degradation (increases with age)
2. Limited mitochondrial capacity (your cellular powerhouses decline over time)
3. Methylation demands (NMN conversion requires methyl groups)
4. Oxidative stress (damages cellular machinery)

The Vitality Bundle addresses all these challenges simultaneously:

With NMN alone:

• NAD+ levels rise temporarily
• But CD38 quickly breaks it down
• Methylation may become strained
• Mitochondria may not optimally utilize the extra NAD+

With NMN + Booster:

• NAD+ levels rise AND stay elevated (thanks to apigenin)
• Methylation is supported (thanks to betaine)
• Mitochondria are optimized to use NAD+ efficiently (thanks to CoQ10)
• Sirtuins are activated to convert NAD+ into cellular benefits (thanks to resveratrol and pterostilbene)

The Bottom Line: Invest in Your Cellular Health

Aging is inevitable, but how you age is increasingly within your control. The science is clear: maintaining healthy NAD+ levels is one of the most important things you can do for longevity and vitality.

But here’s what the research has taught us: it’s not just about raising NAD+, it’s about creating an optimal cellular environment where NAD+ can be produced, protected, and properly utilized.

AVEA’s Vitality Bundle does exactly that. By combining NMN with six synergistic ingredients, each targeting a different aspect of the NAD+ cycle, you’re not just supplementing, you’re optimizing your cellular health at the deepest level.