Resveratrol supplements for longevity: benefits, dosages, side effects

Did you know that all the hype surrounding red wine and longevity is actually related to a natural compound called Resveratrol? 

Now, alcoholism is not a great idea, so don’t go fill up your kitchen shelf with red wine.

Instead, explore the health-boosting powers of this antioxidant, and find out the healthier ways you can consume it to boost your longevity in this Avea article.

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Resveratrol for anti-ageing

More than 12,000 scientific papers about Resveratrol have been published in preventing or slowing down the progression of multiple illnesses.

Resveratrol could be a safe and effective strategy when it comes to enhancing longevity and minimising the risk of age-related diseases.

What is Resveratrol?

Resveratrol is a powerful polyphenol found in certain plants, where it serves as a natural defence mechanism against environmental stressors like UV radiation, infections, and extreme weather conditions.

This compound is known for its antioxidant properties, helping protect cells from damage, and has gained attention for its potential role in promoting longevity and overall health, including cardiovascular support and anti-inflammatory benefits.

Natural sources of Resveratrol

Resveratrol can be found in several plants and foods, including:

  • Japanese knotweed
  • Red grapes and grape skins
  • Peanuts
  • Berries, such as blueberries and cranberries
  • Red wine (due to its grape content)

5 benefits of supplementing with Resveratrol

Whilst many studies on Resveratrol have been conducted on cell cultures or animals, making it difficult to draw definitive conclusions for humans, the potential benefits are promising.

Longevity experts like Dr. David Sinclair, who is a renowned advocate for Resveratrol, believe it plays a key role in promoting healthy ageing.

impact resveratrol in your body

1. Effect of Resveratrol supplements on the brain

Resveratrol demonstrated protective effects against neurodegenerative diseases[1] by:

  • enhancing the secretion of neurotransmitters (important chemical messengers in your brain cells)
  • promoting neurogenesis (brain cells production)
  • decreasing neuroinflammation and oxidative stress (chaotic states).

2. Effect of Resveratrol supplements on the heart

Resveratrol can protect against ageing-associated vascular diseases [2] like atherosclerosis through multiple studied mechanisms.
It:

  • reduces superoxide (damaging free radicals) generation
  • decreases oxidative stress
  • regulates the renin-angiotensin system.

3. Effect of Resveratrol supplements on cancer

Resveratrol has been found to inhibit tumour progression [3] by suppressing cell proliferation and metastasis (when cancer spreads to a different body part from where it started).

Further studies in human colon cancer cell lines have also revealed how Resveratrol can induce apoptotic cell death, a process that eliminates damaged, virus-infected and cancer cells.

Dr. David Sinclair and Dr. Andrew Huberman views on Resveratrol and NAD+.

4. Effect of Resveratrol supplements bone health

A clinical study in 2020 even revealed how regular supplementation with 75 mg of Resveratrol twice daily, has potential to delay bone loss [4] in the lumbar spine and femoral neck of postmenopausal women.

5. Effect of Resveratrol supplements on skin health

Resveratrol can have a two-fold effect, both on neutralising free radicals and boosting antioxidant levels, so your skin can better defend and repair itself [5].

How much Resveratrol should I take per day?

The recommended dosage is approximately 12.5 mg per kg of body weight, based on an 80 kg adult. T

his estimate comes from animal studies, where doses of 5–100 mg/kg of body weight are often required to achieve specific biological effects.

To get 100 mg of Resveratrol, you need to consume around 8-9 L of red wine daily.

And come now, folks, we all know how harmful too much alcohol can be. If you’re pregnant or have heart conditions, you should probably avoid alcohol altogether.

Best Resveratrol supplement

This is when longevity supplements like the Avea Bundle comes in handy.

The synergistic effects of Resveratrol with other antioxidants and our NAD+ precursor, has guided the innovative product development of this longevity supplement duo.

Avea Vitality Bundle

Our science-backed solution provides:

  1. NAD+ precursor
  2. 6 natural ingredients which target diverse mechanisms of ageing at cellular level.

We included 150 mg of Resveratrol in our Booster for its ability to work with our NAD+ precursor to boost and maintain healthy NAD+ levels.

Taken together, these supplements promote metabolic health and slow down the ageing process. Consuming the recommended daily amount of Resveratrol through diet only is near impossible.

With our high-quality supplements, you are making a scientifically backed choice to support your overall well-being. So why not make Resveratrol a cornerstone in your health and wellness strategy?

I stopped taking Avea’s NMN & Booster for one month-here’s what happened

Trans-Resveratrol v.s Resveratrol supplements: which one is better?

Trans-Resveratrol is the active, more bioavailable form of Resveratrol, making it the preferred choice in supplements for enhanced absorption and effectiveness.

Avea contains 150 mg of Trans-Resveratrol, selected for its potency, bioavailability, and purity. Our science-backed formulas are designed to deliver synergistic benefits, ensuring optimal efficiency and results.

The best anti-ageing supplements

  • All-star longevity ingredients like NMN, Resveratrol, CoQ10, and more.
  • Promote healthier ageing at the cellular level.
  • Maximise your energy production.
  • Improve your mental clarity and focus.

When is the best time to take Resveratrol supplement?

The best time to take a Resveratrol supplement is in the morning.

Whilst taking it with food can enhance absorption, Avea’s Resveratrol is formulated with olive oil, which boosts absorption on its own—so you can take it without a meal if needed, offering flexibility for your routine.

Pterostilbene v.s Resveratrol

Pterostilbene is a close relative of Resveratrol but offers several key advantages due to its enhanced chemical structure.

As a dimethylated derivative of Resveratrol, Pterostilbene has a superior bioavailability and absorption.

Studies highlight the following key differences between Pterostilbene and Resveratrol:

  • 80% bioavailability for Pterostilbene v.s 20% for Resveratrol (4x better absorption)
  • Longer half-life: 105 minutes for Pterostilbene vs. 14 minutes for Resveratrol
  • More stable, less prone to oxidation and light sensitivity, ensuring better effectiveness.

Avea’s Vitality Bundle provides an optimal dosage of both, maximising their synergy so you can reap the benefits of each.

Side effects of Resveratrol supplements

No side effects have been observed at short-term doses of up to 1.0 g per day.

Higher doses (2.5 g or more per day) may cause:

  • Nausea
  • Vomiting
  • Diarrhoea
  • Liver dysfunction in patients with non-alcoholic fatty liver disease (NAFLD)

Long-term safety at high doses remains under-researched.

References[+]

By Aishani Rajarai

Aishani Rajarai is a scientific writer and neuroscience enthusiast. She holds a BSc in biochemistry and cell biology, and a minor in medicinal chemistry and chemical biology. Her mission at Avea is to bring the science of longevity through blog posts, newsletters, podcasts, and social media content to the public, so people can live a healthier, longer, and happier life.

Aishani Rajarai is a scientific writer and neuroscience enthusiast. She holds a BSc in biochemistry and cell biology, and a minor in medicinal chemistry and chemical biology. Her mission at Avea is to bring the science of longevity through blog posts, newsletters, podcasts, and social media content to the public, so people can live a healthier, longer, and happier life.

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