In the realm of natural health, few substances bridge the gap between ancient remedies and cutting-edge medical research as elegantly as Berberine.
This vibrant yellow compound, derived from the bark, roots, and rhizomes of various plants, has been a cornerstone in traditional medicine for over two millennia.
Today, it captivates the scientific world, not just for its historical significance, but for its proven potential in contemporary health interventions.
Join us as we delve into the science behind Berberine, understanding why it deserves a place in your daily wellness routine.
In this article
What is Berberine?
Berberine is a bioactive compound classified as a polyphenol.
Polyphenols are produced as a defence mechanism against attack from fungi, bacteria, or insects.
They are essential for plant diversity, accounting for their flavour, colour, bitterness, and nutritional properties of plant-based foods.
Historically used for over 2500 years in Ayurvedic and Chinese medicine to treat myriad ailments, modern science has begun to unveil the mechanisms behind its remarkable therapeutic effects.
This can be evidenced by the 630+ papers published on Berberine in PubMed, in 2020 alone.
Where can Berberine be found in nature?
Many plant species contain Berberine including goldthread, Oregon grape, and barberry. Plants of this genus are often used against inflammation, infectious diseases, diabetes, constipation, and other pathologies.
These plants have not only survived, but thrived across different continents, from the Himalayas to North America, carrying with them a legacy of healing and health maintenance.
Whilst multiple studies revealed the beneficial effects of supplemental Berberine and barberry extracts, the relative amount of fresh or dried barberries to be consumed remains unclear.
Mechanism of action of Berberine
Berberine stands out for its ability to activate AMP-activated protein kinase (AMPK), an enzyme often referred to as the ‘metabolic master switch’. AMPK plays a crucial role in regulating energy balance at both the cellular and whole-body levels.
When activated by Berberine, AMPK enhances glucose uptake and fat breakdown, whilst reducing the production of glucose in the liver.
This activation mirrors the beneficial effects typically associated with physical exercise and caloric restriction, making Berberine a potent tool for metabolic health.
Its health benefits have been extensively studied in clinical trials for lowering blood sugar, lipids, high cholesterol and hypertension.
No significant difference has been observed between the effects of Berberine and other Type II diabetes prescription drugs like metformin. In fact, both studies show similar declines in HbA1c levels (a marker of glucose management in diabetics), with no remarkable side effects from Berberine.
So let’s find out the health benefits of supplementing with Berberine.
Turns out, it will not only improve your blood-sugar levels, but also enhance your immune system and promote healthy brain cell production.
Health benefits of Berberine
1. Metabolic health
One of the most significant impacts of Berberine is on metabolic health, particularly its ability to improve insulin resistance and manage blood sugar levels.
Studies have consistently shown that Berberine can reduce blood glucose levels to a degree comparable to that of conventional diabetes medications like metformin.
By enhancing insulin sensitivity, Berberine not only helps control blood sugar levels, but also contributes to overall metabolic syndrome improvements.
This makes it a valuable option for not only those managing Type 2 diabetes or pre-diabetes, but also any smart fellow out there trying to increase his or her longevity.
2. Cognitive and immune benefits
Beyond its metabolic benefits, Berberine also exerts protective effects on brain health and immune system function.
Research indicates that Berberine can enhance cognitive functions, potentially through its anti-inflammatory properties and ability to reduce oxidative stress.
These actions are beneficial in slowing cognitive decline and may offer protective mechanisms against neurodegenerative diseases.
Additionally, its immune-enhancing properties help fortify your body’s defences against various pathogens and diseases.
3. Cardiovascular protection
Berberine’s benefits extend to cardiovascular health as well. It has been found to improve cholesterol levels by increasing the removal of LDL (bad) cholesterol from the bloodstream and reducing triglyceride levels.
It can also aid in lowering blood pressure, further reducing the risk of heart disease and stroke. These cardiovascular benefits are particularly important for those with metabolic conditions, as they often face higher risks of heart-related issues.
The Avea Stabiliser
Our Stabiliser is a revolutionary natural blood sugar stabilising formula that blocks the absorption of carbs by up to 40% while you eat. Here’s the real kicker: it helps you avoid blood sugar spikes and crashes while still allowing you to enjoy the foods you love.
Why are we unique?
Our uniqueness also stems from the additional benefits brought in by Reducose®and Chromium Picolinate, included in our Stabiliser alongside Berberine.
As a whole, the 3 chosen ingredients work in synergy to safely boost your body into a fat-burning mode, further helping you maintain a healthy blood-sugar level.
For instance, while Berberine will act by lowering your fasting glucose levels, Reducose® will act on your post-meal glucose levels.
To top it off, Chromium will assist by considerably increasing your insulin activity. Our stabiliser is the ultimate key to a healthy heart and a healthy weight!
Why do we use Berberine in our supplement?
We chose Berberine because of its potential to activate the crucial enzyme AMPK, which essentially generates the same benefits as exercising, dieting or weight management—the healthy lifestyle modifications you know you should implement when it comes to improving your health, but which can sometimes still be challenging. On the plus side, Berberine has the same effects as increasing exercise and restricting your calorie intake altogether. Regardless, you should still follow a healthy lifestyle.
When used in combination with other agents, Berberine has consistently exhibited multiple pharmacological and therapeutic actions, such as antioxidant and immunomodulatory effects, protective action on the cardiovascular system, liver and kidney, endothelial relaxation, as well as regulator of glucose metabolism.
This is yet another major reason why we chose Berberine to partner with the other two ingredients in our Stabiliser supplement. For instance, Berberine acts by lowering your fasting glucose levels, while Reducose on the other hand, will act on your post-meal glucose levels.
User testimonials
Our customers have experienced first-hand the transformative effects of Stabiliser. Many report feeling more energetic and less prone to the highs and lows of blood sugar fluctuations, which are often associated with mood swings and energy dips.
Safety and dosage
The safety of our customers is paramount, which is why the dosage of Berberine in Stabiliser is carefully calibrated to maximise benefits without risking discomfort or interactions with other medications.
Our supplement is crafted based on the latest research to ensure that each dose provides an optimal amount of Berberine, achieving the desired health benefits whilst maintaining safety standards.
By adhering to the recommended daily intake on our packaging, users can confidently incorporate Stabiliser into their health regimen, knowing they are consuming a scientifically supported, safe, and effective product.
A keynote from Avea
From the dense forests where traditional healers first discovered its benefits, to the cutting-edge laboratories confirming its potent health impacts, Berberine stands as a testament to the convergence of historical wisdom and modern science.
As we’ve explored the multifaceted benefits of Berberine, it’s clear why this ancient remedy has found its place in our Stabiliser supplement. It not only promises enhanced metabolic health, but also supports cognitive and cardiovascular well-being.
We invite you to experience the transformative effects of Berberine and join our community of health enthusiasts who are turning to nature’s proven secrets for a healthier life
References:
- Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation – PMC
- Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) | Nature Communications
- Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression
- Berberine and probiotics combo successful in reducing blood sugar level in diabetic patients – China 12-week RCT
- Comparison Among Garlic, Berberine, Resveratrol, Hibiscus sabdariffa, Genus Zizyphus, Hesperidin, Red Beetroot, Catha edulis, Po
- Berberine Prolongs Life Span and Stimulates Locomotor Activity of Drosophila melanogaster – PMC
- Berberine in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis
- Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine
- Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes
- Clinical Applications for Berberine | Natural Medicine Journal
- Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression – Dang – 2020 – Aging Cell – Wiley Online Library
