Ageing is inevitable—but how you age is within your control. Scientists have discovered that one natural compound could be a game-changer for healthy ageing: Fisetin.
This flavonoid does what most antioxidants can’t—it actively eliminates senescent cells, the ‘zombie’ cells that accelerate ageing and inflammation. Even famous Dr. David Sinclair takes a Fisetin supplement daily.
Research shows that Fisetin goes beyond simple cellular support. It has been linked to increased lifespan in animals, improved brain function, and a reduction in inflammation—key factors in slowing biological ageing.
With its unique senolytic ability to target ageing at the root, it’s becoming a must-have for anyone serious about longevity.
Read on to discover the benefits of Fisetin.
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What is Fisetin?
Fisetin is a naturally occurring flavonoid, a type of plant compound renowned for its vibrant colouration and antioxidant properties.
Chemically, it belongs to the flavonol subgroup, characterised by its unique molecular structure that contributes to its biological activity.
Where can you find Fisetin in nature?
Fisetin is found in a variety of fruits and vegetables, including strawberries, apples, persimmons, and onions.
Biological sources
| Plant source | Amount of Fisetin (μg /g) |
|---|---|
| Strawberry | 160 |
| Apple | 26 |
| Persimmon | 10.6 |
| Onion | 4.8 |
What are the benefits of Fisetin?
Fisetin acts as a potent antioxidant, combats inflammation, and, most notably, exhibits senolytic properties.
This means Fisetin can selectively target and clear senescent cells – ageing cells that have stopped dividing and contribute to age-related decline and diseases.
Senescent cells are often called Zombie cells, because they are no longer dividing or functioning properly, but still remain metabolically active.
Its ability to influence cellular ageing processes positions Fisetin at the forefront of longevity research, making it a subject of considerable interest for those exploring natural interventions for healthy ageing.
How does Fisetin work?
The comprehensive benefits of Fisetin span several aspects of health and wellbeing.
1. Fisetin has senolytic properties
Fisetin functions as a senolytic by selectively targeting and eliminating senescent cells. These are cells that have ceased dividing and contribute to ageing and age-related diseases.
Senescent cells accumulate in tissues over time, secreting harmful inflammatory factors and enzymes that degrade tissue function. The accumulation of senescent cells is a hallmark of ageing, known as cellular senescence.
Studies suggest that Fisetin reduces cellular senescence through the induction of apoptosis, or programmed cell death, in senescent cells, while sparing healthy cells. In short, Fisetin gets rid of the zombie cells whilst protecting the healthy ones.
This selective action of Fisetin not only promotes a healthier cellular environment, but also enhances overall tissue function and longevity.
Learn more about senolytics here.
2. Fisetin provides anti-inflammatory effects
Fisetin exerts anti-inflammatory effects by modulating various signalling pathways that are involved in the inflammatory response.
It inhibits the activity of certain proteins, reducing inflammation at the molecular level.
Fisetin also downregulates the production of pro-inflammatory molecules, which play significant roles in chronic inflammation.
By suppressing these inflammatory mediators, Fisetin can mitigate the effects of chronic inflammation, which is a root cause of many age-related diseases.
Its ability to cross the blood-brain barrier also suggests potential benefits in neuroinflammatory conditions, offering a protective effect against neurodegeneration.
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3. Fisetin as an antioxidant
As an antioxidant, Fisetin scavenges free radicals, which are unstable molecules that can cause oxidative stress and damage to cells.
It enhances the body’s endogenous antioxidant defences, boosting the activity of enzymes like superoxide dismutase and catalase.
Fisetin’s ability to reduce oxidative stress is linked to its chemical structure, which allows it to donate electrons to neutralise free radicals effectively.
This antioxidant action contributes to the protection of cells from DNA damage, lipid peroxidation, and protein degradation, which are common in ageing.
Fisetin’s role in maintaining cellular redox balance is crucial in preventing the onset of various oxidative stress-related diseases, including cardiovascular and neurodegenerative disorders.
Discover 6 antioxidants you should know about.
4. Fisetin in fighting cancer
Fisetin has demonstrated potential in combatting cancer by inducing apoptosis in cancer cells, a process that facilitates the removal of tumour cells.
Its anti-inflammatory properties play a crucial role in reducing compounds that contribute to chronic inflammation and cancer progression.
In colorectal cancer patients, Fisetin has been observed to lower levels of pro-inflammatory mediators.
Fisetin enhances autophagy, the cellular housekeeping mechanism that maintains normal cell function. This enhanced autophagy can inhibit the survival of cancer cells.
Learn more about autophagy here.
It contributes to the prevention of angiogenesis in cancer, thereby starving tumour cells of essential nutrients like oxygen and glucose.
Fisetin helps in preventing oxidative damage, which is a significant factor in DNA mutations and the development of cancer.
Fisetin may also inhibit cancer cell migration and metastasis, potentially limiting the spread of cancer to different parts of the body.
5. Fisetin in preventing obesity and diabetes
Fisetin acts as a metabolic control switch, reducing fat cell accumulation and suppressing the activation of mTOR, a protein linked to weight gain.
In animal studies, Fisetin has shown efficacy in preventing weight gain and the accumulation of harmful white fat tissue in subjects on a high-fat diet.
It also combats fat accumulation in the liver, a common issue in metabolic diseases, which can compromise liver function and lead to fatty liver disease.
Fisetin presents potential benefits for individuals suffering from type II diabetes, as evidenced in rodent models, where it lowered body weight and improved glucose control.
In diabetic mice, Fisetin significantly reduced the severity of complications, such as slowing the progression of cataracts, preventing kidney damage, and enhancing kidney function.
A human trial is currently underway to explore Fisetin’s ability to protect kidney function, especially in diabetes patients, highlighting its promising role in managing and potentially preventing diabetes-related complications.
Molecular and therapeutic effects of Fisetin flavonoid in diseases.
How should I take Fisetin?
Combining Fisetin and Quercetin may amplify their health benefits due to their synergistic effects. Which one is better?
Quercetin, another flavonoid with powerful anti-inflammatory and antioxidant properties, complements Fisetin’s senolytic activity.
Together, they could potentially enhance cellular health and longevity more effectively than when taken separately.
This combination could lead to a more robust defence against oxidative stress and inflammation, both key factors in ageing and chronic diseases.
Learn more about Quercetin benefits.
Where can I buy the best Fisetin supplement?
Packed with 6 well-researched ingredients including Quercetin, Fisetin, PQQ, Ergothioneine, Spermidine, and Selenium, Avea’s Cell Primer offers a comprehensive approach to maintaining cellular health and vitality.
The Cell Primer is a revolutionary supplement for cellular health, targeting three key mechanisms:
- promoting autophagy for cellular cleansing
- clearing senescent cells to combat ageing
- defending against oxidative stress for optimal cell revitalisation.
The best anti-ageing supplements
- Get rid of senescent cells.
- Balance your gut microbiome
- Reduce inflammation at its root.
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The Inflammaging Routine is an innovative duo designed to counteract the main cause of ageing – inflammation – so you can improve your cognitive and physical health daily.
- Balance your gut microbiome with Biomind: A next-gen probiotic promoting gut microbiome balance to reduce systemic inflammation.
- Clear out senescent cells with Cell Primer: Contains powerful senolytics like Fisetin and Quercetin, and antioxidants to eliminate inflammation-causing aged cells, support autophagy and boost mitochondrial health.
When combined with other ingredients, Fisetin enhances overall cellular function, supports healthy ageing, and contributes to a lower biological age and potentially healthier lifespan.
